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Klaus Giese Selected Research

Atu027

12/2014First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors.
1/2012Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors.
11/2010Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models.
12/2008Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression.

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Klaus Giese Research Topics

Disease

6Neoplasms (Cancer)
12/2014 - 06/2002
3Prostatic Neoplasms (Prostate Cancer)
11/2010 - 11/2003
2Neoplasm Metastasis (Metastasis)
12/2014 - 11/2010
2Lymphatic Metastasis
11/2010 - 12/2008
1Edema (Dropsy)
12/2023
1Inflammation (Inflammations)
12/2023
1Lewis Lung Carcinoma
11/2010
1Neoplasm Micrometastasis
11/2010
1Pancreatic Neoplasms (Pancreatic Cancer)
12/2008
1Hypoxia (Hypoxemia)
02/2005

Drug/Important Bio-Agent (IBA)

5Small Interfering RNA (siRNA)IBA
01/2012 - 11/2003
4Atu027IBA
12/2014 - 12/2008
3Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
02/2005 - 06/2002
1NucleosidesIBA
12/2023
1LipopolysaccharidesIBA
12/2023
1Messenger RNA (mRNA)IBA
12/2023
1Therapeutic UsesIBA
12/2014
1cadherin 5IBA
11/2010
1Proteins (Proteins, Gene)FDA Link
11/2010
1protein kinase NIBA
12/2008
1Sirolimus (Rapamycin)FDA Link
02/2005
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
02/2005
12- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA
02/2005
1Phosphatidylinositols (Phosphatidylinositol)IBA
06/2002
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
06/2002

Therapy/Procedure

1Intravenous Infusions
12/2014
1Premedication
12/2014
1Intravenous Administration
11/2010
1Therapeutics
11/2010